Colorectal liver metastases: Tranexamic acid reduces blood transfusions after hepatectomy
Canada: Intraoperative administration of tranexamic acid (TXA) decreases red blood cell transfusions (RBCT) in hepatectomy for colorectal liver metastases (CRLM), according to a recent study in the journal HPB. The study found that TXA led to a 41% reduction in the risk of 30-day receipt of RBCT.
Colorectal cancer is a major health problem and is the third most common cancer in the world. About 65% of all the CRC patients develop distant metastasis, the most common site being the liver (40%) -- colorectal liver metastases. Liver resection remains the most important modality in the treatment of colorectal liver metastases. But, RBCT remain a concern for patients undergoing hepatectomy.
Alisha A. Jaffer, Sunnybrook Research Institute Toronto, ON, Canada, and colleagues examined the effect of TXA, anti-fibrinolytic, on receipt of RBCT in CRLM metastases.
The researchers included hepatectomies for CRLM over 2009–2014. The primary outcome was 30-day receipt of RBCT. A total of 433 patients were included, of which,146 (34%) received TXA.
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