Corticosteroids Improve Survival rate after Cardiac Surgery among Patients Under 65 Years, suggests research
A recent meta-analysis published in the Journal of Cardiothoracic and Vascular Anesthesia illuminated the potential life-saving benefits of corticosteroids in cardiac surgery patients younger than 65. This comprehensive study reviewed data from 17 randomized trials and encompassed a total of 6,598 patients which indicated that corticosteroids could reduce mortality rates among this demographic.
Cardiac surgeries which involve cardiopulmonary bypass (CPB) are often complicated by the development of a systemic inflammatory response syndrome (SIRS). This inflammatory response can contribute to postoperative morbidity and mortality. While corticosteroids can reduce inflammation, their overall impact, has been unclear and possibly age-dependent after considering potential harm versus benefit.
The systemic review by Rosario Losiggio and team focused on the cardiac surgeries performed with CPB. This included patients younger than 65 years old involving both pediatric and non-elderly adult populations. The primary intervention measured was the perioperative use of corticosteroids when compared to placebo or standard care.
This study utilized data from PubMed, EMBASE and the Cochrane Library after covering literature from their inception until January 20, 2024. The primary outcome evaluated mortality that was at the longest follow-up available. The secondary outcomes included acute kidney injury, atrial fibrillation, myocardial injury, cerebrovascular events and infections.
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