Cryoablation Safe for Breast Cancer Patients who are poor surgical candidates: Study
Researchers have found that breast cancer cryoablation can be safely applied to a broader patient population, including those ineligible for clinical trials due to unfavorable patient or tumor characteristics. A recent study was published in the the American Journal of Roentgenology by Karim O. and colleagues. This study highlights the safety and effectiveness of cryoablation in treating breast cancer without surgical excision, offering a viable alternative for patients who are poor surgical candidates.
Cryoablation is a minimally invasive treatment to kill cancer cells through extreme cold. While clinical trials have shown this to be effective, highly stringent inclusion criteria exclude those patients whose diseases are potentially treatable. This study evaluated the safety and outcomes of cryoablation in a real-world setting on patients excluded from clinical trials.
This was a retrospective study of women with cryoablation of biopsy-proven unifocal primary breast cancer treated with locally curative intent without surgical excision at seven institutions between January 1, 2000, and August 26, 2021. Adverse events were recorded. Cryoablation procedures were considered to be technically successful when they were not aborted prematurely and intended treatment parameters had been reached with no residual disease on the first imaging follow-up. Follow-up biopsy results were noted, and ipsilateral breast tumor recurrences were identified and classified as true recurrence versus new primary disease. A competing-risk model estimated the cumulative incidence of IBTR accounting for death before IBTR.
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