Early Sepsis Control associated with Lower 90-Day Mortality: JAMA

Early sepsis control is associated with lower 90-Day mortality, according to new study. Source control within 6 hours of sepsis onset was associated with a reduced risk-adjusted odds of 90-day mortality.
The study has been published in JAMA Surgery.
Early management of sepsis requires respiratory stabilization. All patients should be given supplemental oxygen. Mechanical ventilation is recommended when supplemental oxygen cannot improve oxygenation if the respiratory failure is imminent, or when the airway cannot be maintained. Rapid source control is recommended to improve patient outcomes in sepsis. Yet there is little data to guide how quickly source control is needed.
A group of researchers conducted a study to determine the relationship between time to source control and patient outcomes in community-acquired sepsis. Multi-hospital integrated healthcare system cohort study of hospitalized adults with community-acquired sepsis (January 1, 2013 - December 31, 2017) identified by Sepsis-3 who underwent source control procedures. Follow-up continued until January 1, 2019, and data analyzes were completed on March 17, 2022.
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