Endoscopic sleeve gastroplasty provides better weight reduction than intragastric balloon

A new study by K. Kozlowska-Petriczko and team found that compared to Intragastric balloon (IGB) installation, endoscopic sleeve gastroplasty (ESG) resulted in more weight reduction. The findings of this study were published in Obesity Surgery Journal.

Overweight and obesity are presently a significant worldwide public health burden. Their global prevalence is substantial and steadily increasing, with an estimated 39% adult global population. Although lifestyle adjustments, medication, and food are readily accessible, they appear to be insufficient for the vast majority of patients. In 50% of instances, a 5-10% total body weight reduction (TBWL) can be accomplished with strong patient participation. Weight loss procedures such as intragastric balloon insertion and endoscopic sleeve gastroplasty are proven to be effective and safe. As a result, the purpose of this study was to examine the effects of 6-month IGB therapy, 12-month IGB therapy, and ESG.

Weight loss at 6 months after IGB (Orbera) removal (124 patients), 12 months after IGB (Orbera365) removal (61 patients), and 6 and 12 months following ESG (42 and 34 patients, respectively) were retrospectively examined for this study. Postprocedural care, including prescription and food, was ensured to be consistent throughout all surgeries.

The key findings of this study were:

Patients receiving IGB implantation for 6 and 12 months, as well as ESG after 6 and 12 months, had mean TBWLs of 15.2, 15.8, 26.5, and 28.7 kg, respectively.

There was no statistically significant difference in mean%TBWL between patients who had IGB placement for 6 or 12 months (15.3% vs. 14.7%, P = 0.7).

After 6 months (15.3 vs. 19.8, P = 0.005) and 12 months (14.7 vs. 22.5, P = 0.001), ESG patients had substantially higher mean%TBWL than IGB patients.

In conclusion, all three strategies investigated were beneficial for weight reduction. There was no significant difference in results between 6-month and 12-month IGB treatments. ESG showed to be a more effective therapy strategy for obesity than IGB.

Reference: 

 Kozłowska-Petriczko, K., Pawlak, K. M., Wojciechowska, K., Reiter, A., Błaszczyk, Ł., Szełemej, J., Petriczko, J., & Wiechowska-Kozłowska, A. (2022). The Efficacy Comparison of Endoscopic Bariatric Therapies: 6-Month Versus 12-Month Intragastric Balloon Versus Endoscopic Sleeve Gastroplasty. In Obesity Surgery. Springer Science and Business Media LLC. https://doi.org/10.1007/s11695-022-06398-x