Ester form of hyaluronic acid matrix alongwith negative pressure wound therapy helps in better wound healing

An eHAM (Hyalomatrix; Medline Industries) was utilised in the current study by the authors to treat wounds after extensive surgical debridement and wound bed preparation. Five patients received NPWT plus eHAM treatment (group 1), whereas five patients received NPWT only (group 2). During the course of therapy, every patient had at least 1 autologous skin transplant (STSG or FTSG). The number of weeks until wound closure, the rate of wound closure, the number of weeks until skin transplant, and the rate of skin graft were compared between group 1 and group 2 using T tests with unequal variance.

The key findings of this study were:

1. Despite an almost twice bigger initial wound size, the average time to closure was comparable between group 1 and group 2 (15.2 weeks versus 14.6 weeks).

2. However, group 1 saw a higher rate of wound closure each week than group 2, both in terms of area (9.0 cm2 vs. 6.8 cm2) and volume (12.3 cm3 vs. 5.4 cm3).

3. Additionally, group 1 had a faster rate of wound closure each week following skin grafting in terms of both area (4.5 cm2 vs 3.8 cm2) and volume (25.9 cm3 vs 4.1 cm3).

4. Skin grafts were administered to every patient in group 1 within two to three weeks of their second eHAM administration.

Reference:

Robertson, T., & Benitez, L. (2023). Reduced Time to Skin Grafting in Chronic Wounds Using an Esterified Hyaluronic Acid Matrix and Negative Pressure Wound Therapy. In Wounds: a compendium of clinical research and practice (Vol. 35, Issue 5, pp. 99–107). HMP Communications, LLC. https://doi.org/10.25270/wnds/21081