Faecal Elastase-1 Test May Help Diagnose Pancreatic Exocrine Insufficiency After Pancreatic Resection: Study

For this purpose, the researchers reviewed PEI diagnostic tests using a combined text and MeSH search strategy to identify relevant articles on post-pancreatectomy PEI diagnosis.

Key Findings:

• The literature search identified 4,874 records, of which 30 studies with 2,305 patients were included in the analysis.
• The reported incidence of PEI varied widely across studies, though more than two-thirds of the included papers indicated a prevalence exceeding 65% in patients who underwent pancreatoduodenectomy or distal pancreatectomy.
• The fecal elastase-1 (FE-1) test was the most commonly used diagnostic tool for post-pancreatectomy PEI.
• Six studies compared the diagnostic accuracy of FE-1 with fecal fat tests or 13C breath tests, finding no significant differences.
• Five studies examined micronutrient deficiencies in patients with post-pancreatectomy PEI.

The researchers state that post-pancreatectomy PEI remains a significant health concern, with challenges in accurate diagnosis and comprehensive patient assessment. The fecal elastase-1 test was the most commonly used diagnostic tool; however, well-structured studies comparing its accuracy with other diagnostic methods are limited. Research on key aspects such as micronutrient deficiencies, anthropometric variations, weight recovery time, and patient-reported outcomes is also scarce.

"Moving forward, establishing a gold standard for diagnosing and assessing the severity of post-pancreatectomy PEI is crucial. Additionally, future studies should focus on evaluating risk factors across different patient groups and developing tailored pancreatic enzyme replacement therapy strategies to optimize patient care," they concluded.

Reference:

Di Martino, M., de la Hoz Rodriguez, Á., Saibanti, A. et al. Pancreatic exocrine insufficiency after pancreatic resection: a systematic review. BMC Surg 25, 53 (2025). https://doi.org/10.1186/s12893-025-02787-y