Ileostomy development closely linked to renal function deterioration independent of readmission

A new study by John Panizza and team found that regardless of the patient's needs to be readmitted to the hospital, ileostomy development is linked to a decline in renal function. The findings of this study were published in ANZ Journal of Surgery.

Ileostomy creation may be permanent or only temporary in order to disrupt a pelvic anastomosis that has a high risk of septic complications. However, these treatments have a high readmission rate, which is typically brought on by dehydration and linked to acute kidney injury (AKI).

Patients with a freshly established ileostomy were examined for readmission within 60 days after discharge in this investigation. The idea was that high-risk individuals might be recognized by their clinical traits and that when the ileostomy was electively reversed, they would have worse renal function.

The key findings of this study were:

1. The investigation covered a total of 171 patients, with a 38% readmission rate within 60 days following release.

2. Both the readmission and no readmission groups had substantial increases in creatinine from baseline blood tests compared to the day of elective ileostomy closure.

3. In both the readmission and no readmission groups, there was a substantial decline in eGFR from baseline blood tests compared with the date of ileostomy closure.

4. At the time of ileostomy closure, there was no discernible change in creatinine levels or eGFR between the readmission and no readmission groups.

5. In the readmission group compared to the no readmission arm, baseline serum sodium levels were lower.

The development of an ileostomy is linked to a statistically significant decline in renal function. All types of ileostomy patients must be included in any future research on techniques for enhancing hydration concluded the Authors.

Reference:

Panizza, J., Swee, Y. J. S., Edmundson, A., & Clark, D. (2023). Renal dysfunction occurs following ileostomy formation and is independent of readmission. In ANZ Journal of Surgery. Wiley. https://doi.org/10.1111/ans.18254