Metabolic Surgery Reduces Liver Disease Risk in Patients with MASH-Related Cirrhosis: Study
A recent study found metabolic surgery to demonstrate significant benefits in lowering the risk of major adverse liver outcomes (MALO) for cirrhosis patients due to metabolic dysfunction-associated steatohepatitis (MASH). The findings published in the recent issue of Nature Medicine journal suggest that surgical intervention could provide a safer and more effective treatment option when compared to traditional nonsurgical management.
Cirrhosis is marked by scarring and impaired function of liver which often progresses without clear therapeutic solutions. The patients with obesity and histologically confirmed MASH-related cirrhosis face elevated risks of liver failure and related complications. Despite advancements in research, no medical therapy has proven effective at reducing these risks so far.
The Surgical Procedures Eliminate Compensated Cirrhosis In Advancing Long-term (SPECCIAL) study tracked 62 patients who underwent metabolic surgery and compared their outcomes to 106 nonsurgical controls over an average follow-up period of 10 years. The surgery group was predominantly female (68%), as was the control group (71%). The study employed robust estimation methods to balance key baseline characteristics between the two groups by ensuring reliable results.
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