Portal venous system thrombosis after bariatric surgery rare but lethal: Study
China: The incidence of portal venous system thrombosis after bariatric surgery is rare but can be potentially lethal, finds a recent review in the journal Surgery. Considering this, the researchers suggest the consideration of extended prophylactic anticoagulation protocol in patients at high risk of developing portal venous system thrombosis after bariatric surgery.Prior to the study, it...
China: The incidence of portal venous system thrombosis after bariatric surgery is rare but can be potentially lethal, finds a recent review in the journal Surgery. Considering this, the researchers suggest the consideration of extended prophylactic anticoagulation protocol in patients at high risk of developing portal venous system thrombosis after bariatric surgery.
Prior to the study, it was known that portal venous system thrombosis can develop after bariatric surgery. Xingshun Qi, General Hospital of Northern Theater Command, Shenyang, China, and colleagues conducted the systematic review and meta-analysis to evaluate the incidence of portal venous system thrombosis after bariatric surgery and clarify the role of anticoagulation for the prevention of portal venous system thrombosis after bariatric surgery.
For this purpose, the researchers searched the online databases. The incidence of portal venous system thrombosis after bariatric surgery was pooled by a random-effect model. Subgroup analyses were performed to explore the incidence of portal venous system thrombosis according to the average duration of prophylactic anticoagulation (extended versus short-term).
68 studies were included. Among 100,964 patients undergoing bariatric surgery, 300 developed portal venous system thrombosis.
Key findings of the study include:
- The pooled overall incidence of portal venous system thrombosis after bariatric surgery was 0.419%.
- The pooled incidence of portal venous system thrombosis after bariatric surgery was numerically lower in patients who received extended prophylactic anticoagulation protocol after bariatric surgery than those who received short-term prophylactic anticoagulation protocol (0.184% vs 0.459%).
- Meta-regression analyses demonstrated that sample size, type of surgery, and average duration of prophylactic anticoagulation might be sources of heterogeneity, but not region, publication year, history of bariatric surgery, follow-up duration, or use of prophylactic anticoagulation.
- Sensitivity analyses could not identify any source of heterogeneity.
- The estimated mortality of portal venous system thrombosis after bariatric surgery was 1.33%.
"Portal venous system thrombosis after bariatric surgery is rare, but potentially lethal," wrote the authors. "Extended prophylactic anticoagulation protocol may be considered in patients at a high risk of developing portal venous system thrombosis after bariatric surgery."
Reference:
The study titled, "Portal venous system thrombosis after bariatric surgery: A systematic review and meta-analysis," is published in the journal Surgery.
DOI: https://www.surgjournal.com/article/S0039-6060(21)00197-5/fulltext
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