Preoperative hs-CRP Linked to Postoperative Incision Complications in MOWHTO: Study

Results: There were 528 participants, including 190 males and 338 females, with a mean age of 56.2 ± 6.5 years. Within the 30 days following surgery, 48 patients (9.1%; 95% CI, 6.6% to 11.5%) experienced incision complications. Both the unadjusted and adjusted RCS analyses revealed the consistently significant nonlinear relationship (P < 0.05). ROC curve analysis identified an optimal hs-CLR cut-off value of 1.83, accordingly categorizing patients into low hs-CLR (n = 298) and high hs-CLR (n = 230) groups. Multivariate analyses employing two adjustment techniques demonstrated a significant relationship between a hs-CLR ≥ 1.83 and an increased risk of incision complications, with an odds ratio of 8.08 (95% CI, 3.16 to 20.63; P < 0.001) for “fully adjusted model” and of 8.99 (95%CI, 3.92 to 20.63; P < 0.001) for “backward elimination model”.

This study demonstrated a robust association between preoperative hs-CLR and the risk of postoperative incision complications following MOWHTO for varus KOA. Although the observed odds ratios were substantial, the wide confidence intervals highlight the need for validation through larger, multicenter studies.

Reference:

Ji, C., Cheng, J., Su, H. et al. Relationship between high-sensitivity C-reactive protein to lymphocyte ratio (hs-CLR) and incision complications following medial opening-wedge high tibial osteotomy for knee osteoarthritis. BMC Surg 25, 230 (2025). https://doi.org/10.1186/s12893-025-02968-9