Prior Cholecystectomy Associated with Increased Osteoporosis Risk

A new study published in Frontiers in Endocrinology found a significant association between prior cholecystectomy an increased risk of developing osteoporosis. The research followed 17,603 individuals who underwent cholecystectomy and 35,206 matched controls, aimed to shed light on the potential health consequences of this common surgical procedure.

Over a median follow-up period of 13.56 years, the researchers identified 3,217 cases of osteoporosis among the study participants. Women who had undergone cholecystectomy were found to be 1.21 times more likely to develop osteoporosis, with a hazard ratio (HR) of 1.21 and a 95% confidence interval (CI) of 1.12–1.31. Similarly, men who had the surgery faced a 1.45 times higher risk, with an HR of 1.45 and a 95% CI of 1.10–1.90.

Interestingly, the study also revealed that the association between cholecystectomy and osteoporosis was more pronounced in specific subgroups. In women, this link was particularly strong for those aged 40–55, individuals with a BMI (Body Mass Index) below 18.5 kg/m², and those with vitamin D levels between 30 and 50 nmol/ml.

Crucially, the study did not identify significant interactions between cholecystectomy and various socio-economic factors such as income and education levels or the presence of other medical conditions like hypertension and diabetes.