Prophylactic Antibiotics Reduce SSI Only in Open Pyloromyotomy Cases, suggests study
Researchers identified that the routine use of prophylactic antibiotics in infants who are having pyloromyotomy might not always prevent surgical site infections (SSI) but could reduce infection incidence significantly in those that have open surgical repair. The study was published in the journal of Annals of Surgery by Kerri A. and colleagues.
To explain these variations in practice, data from 6,093 infants who had pyloromyotomy between January 2021 and December 2023 at 148 hospitals in the NSQIP-Pediatric program were analyzed. The researchers contrasted outcomes among patients who received prophylactic antibiotics with those who did not, using patient-level propensity matching and mixed-effects models.
The study team utilized a strong multicenter design to facilitate generalizability of findings. Propensity-matched comparisons that controlled for patient factors and hospital clusters were utilized to contrast infection outcomes. The study also had a hospital-level analysis to examine if institutional rates of prophylaxis were related to better SSI rates. Subgroup analyses were performed to explore separately infants that received laparoscopic versus open pyloromyotomy and to give a detailed insight regarding surgical approach effect on outcomes.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.