Regional anesthesia cuts recurrence and metastasis rates in cancer patients after surgery
A comprehensive meta-analysis investigating the influence of anaesthesia techniques on cancer recurrence and metastasis following oncological surgery has revealed intriguing findings. This meta-analysis provides compelling evidence suggesting that regional anaesthesia (RA), whether used alone or adjunctively with general anaesthesia (GA), is associated with a lower risk of cancer recurrence, particularly in patients with prostate cancer.
This study was published in the BMC Anaesthesiology by Shuang Xie and colleagues. The study, encompassing 32 studies with 24,724 cancer patients, focused on the potential effects of regional anaesthesia (RA), either independently or combined with general anaesthesia (GA), on these critical outcomes.
Researchers conducted an extensive search across PubMed, Embase, and the Cochrane Library databases. The primary outcome assessed was cancer recurrence, with secondary outcomes including local recurrence and distant metastasis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects models. Quality assessments were performed using the Newcastle-Ottawa Scale (NOS) for observational studies and the Cochrane Risk of Bias Tool for Randomized Trials (Rob 2.0). The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system was utilized to assess all outcomes.
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