Simultaneous Splenectomy Helps Overcome Small-for-Size Graft Syndrome in liver transplant cases
Small-for-size graft (SFSG) syndrome is a major cause of graft loss after living donor liver transplantation (LDLT). Researchers from the Kyushu University, Fukuoka, Japan have found that simultaneous splenectomy can be used to overcome small-for-size graft syndrome. They also found that simultaneous splenectomy improved clinical outcomes in LDLT recipients after propensity-score matching. The research has been published in the Journal of Hepatology on August 19, 2020.
Since the introduction of adult living donor liver transplantation (LDLT), graft size has become a concern, particularly for patients with chronic liver failure and/or portal hypertension. Small-for-size graft (SFSG) syndrome after LDLT remains a major complication of this procedure. Splenectomy (Spx) is an option to prevent this catastrophic complication, but its effect remains controversial. Therefore, a research team of Japan conducted a study to assess the effect of simultaneous Spx on graft function and long-term outcomes after LDLT.
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