Some Oral Antispastic Medications contribute to better Radial Artery Graft Patency Post-CABG: Study
A small Chinese trial evaluated the effects of three oral antispastic medications over 24 weeks in preventing spasm-induced radial artery graft failure after coronary artery bypass grafting (CABG).
The study found that nicorandil and isosorbide mononitrate showed a trend toward better graft patency and fewer instances of hypotension compared to diltiazem. Since graft patency is a major factor limiting the wider use of radial artery grafts in CABG, these findings suggest that medication could help overcome this barrier and promote the greater adoption of this surgical approach.
The optimal treatment to prevent spasms in radial artery grafts after coronary artery bypass surgery remains uncertain. This clinical trial aimed to compare the effects of nicorandil, isosorbide mononitrate, and diltiazem on radial artery grafts.
This was a single-center, randomized, open-label, parallel-group pilot trial. Patients who underwent coronary artery bypass surgery using radial artery grafts were randomly assigned to receive oral nicorandil, isosorbide mononitrate, or diltiazem for 24 weeks after surgery.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.