Statins may prevent adhesion-related complications after intra-abdominal surgery: JAMA

The study involved 2 separate retrospective cohort studies (The Health Improvement Network [THIN] and Optum's Clinformatics Data Mart [Optum]) that compared adults receiving statins versus people who did not receive statins at the time of intra-abdominal surgery.

It included people undergoing intra-abdominal surgery from January 1, 1996, to December 31, 2013, in the United Kingdom and from January 1, 2000, to December 31, 2016, in the US. People with obstructive events before surgery or a history of inflammatory bowel disease were excluded. Data analysis was performed from September 1, 2012, to November 24, 2020.

The primary outcome was ARCs, defined as small-bowel obstruction or need for adhesiolysis, occurring after surgery.

For THIN, a total of 148 601 and for Optum 1 188 217 individuals met the inclusion criteria. 

"This research suggests that statin use may be significantly associated with a decreased probability of ARCs and small-bowel obstructions (SBOs) after intra-abdominal surgery. Future prospective randomized clinical trials of this inexpensive, well-tolerated therapy will be required to confirm these findings," concluded the authors. 

The study titled, "Association Between Statin Use at the Time of Intra-abdominal Surgery and Postoperative Adhesion-Related Complications and Small-Bowel Obstruction," is published in the journal JAMA Network Open.

DOI: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2775824