Statins may prevent adhesion-related complications after intra-abdominal surgery: JAMA

USA: Statins may be an inexpensive, well-tolerated pharmacologic option for the prevention of postoperative adhesion-related complications (ARCs) in people undergoing intra-abdominal surgery, finds a recent study in the journal JAMA Network Open.

The common complications of intra-abdominal surgery are adhesion-related complications (ARCs), including small-bowel obstruction. Statins, which have antifibrotic pleiotropic effects is known to inhibit adhesion formation in murine models but the same as not been assessed in humans. Frank I. Scott, University of Colorado Anschutz Medical Campus, Aurora, and colleagues aimed to assess whether the use of statin at the time of intra-abdominal surgery is associated with ARCs reduction. 

The study involved 2 separate retrospective cohort studies (The Health Improvement Network [THIN] and Optum's Clinformatics Data Mart [Optum]) that compared adults receiving statins versus people who did not receive statins at the time of intra-abdominal surgery.

It included people undergoing intra-abdominal surgery from January 1, 1996, to December 31, 2013, in the United Kingdom and from January 1, 2000, to December 31, 2016, in the US. People with obstructive events before surgery or a history of inflammatory bowel disease were excluded. Data analysis was performed from September 1, 2012, to November 24, 2020.