Supplemental intraoperative oxygen did not increase postoperative mortality, Finds Study

It was a post hoc analysis of a large multiple crossover cluster trial in which more than 5,000 colorectal surgeries on 4,088 adults were allocated to receive either 30% or 80% inspired oxygen during general anaesthesia. The researchers evaluated the effect of 80% versus 30% target-inspired oxygen on long-term mortality and calculated Kaplan–Meier survival estimates. They identified a total of 3,471 qualifying colorectal surgeries performed in 2,801 patients and analyzed 1,753 (51%) surgeries in 1,577 patients who were given 80% oxygen and 1,718 surgeries in 1,551 patients who were given 30% oxygen.

Key findings of the study were:

• Upon analysis, they observed that the incidence of death after a median of 3 yr was 13% (234 of 1,753) in the 80% oxygen group and 14% (245 of 1,718) in the 30% oxygen group.
• They noted that the estimated hazard ratio for mortality was 0.94.

The authors concluded, " We performed a post hoc analysis of a large crossover cluster trial and evaluated whether intraoperative supplemental oxygen causes long-term mortality. Supplemental oxygen did not increase postoperative mortality overall, or in cancer patients, and can be safely used when deemed appropriate."

For further information:

https://doi.org/10.1097/ALN.0000000000003694