Supplemental intraoperative oxygen did not increase postoperative mortality, Finds Study
Surgical site infections and wound-related complications are common and serious. The primary defence against bacterial infection is oxidative killing by neutrophils, which requires molecular tissue oxygen. Increasing inspired oxygen is an easy and effective way to augment tissue oxygen. However, a recent study suggests that supplemental oxygen did not increase postoperative mortality. The research has been published in the journal Anesthesiology on March 05, 2021.
The theory that supplemental oxygen might reduce the risk of surgical wound infection led to two decades of studies. While initial trials were supportive, subsequent large trials were not, and a recent meta-analysis of reliable trials suggests that supplemental oxygen at most slightly reduces the perioperative infection risk. However, the extent to which supplemental oxygen might promote long-term mortality, therefore, remains unclear. Therefore, Dr Qiliang Jiang, M.D. and his team conducted a study to test the hypothesis that supplemental oxygen (80% vs 30%) increases the hazard for long-term mortality.
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