Tumor vessel invasion independent risk factor affecting prognosis of Gastric cancer: Study

Data from 3,205 GC patients were evaluated to look for variations in VI positivity across different clinicopathological factors. To examine the relationship between clinicopathological variables and prognosis, both univariate and multivariate Cox regression models were used. Plotting Kaplan-Meier survival curves helped to better illustrate the results.

This study comprised a total of 3205 individuals, of whom 2216 (69.1%) were VI-negative and 989 (30.9%) were VI-positive. Age, body mass index (BMI), tumor location, pTNM stage, perineural invasion (PI), Lauren classification, and tumor deposit (TD) were shown to be substantially correlated with the VI-positive group, but not with gender or basic illness.

Prior to and during PSM matching, VI-positive patients had a more severe survival rate than VI-negative patients. The patients with VI had a 5-year survival rate of 58.03%, whereas the individuals without VI had a higher rate of 66.25% after PSM.

Furthermore, VI was shown to be a separate risk factor for prognosis by multivariate analysis following matching. Overall, the presence of VI in GC patients is impacted by a variety of parameters, including age, depth of infiltration, BMI, number of lymph node metastases, PI, gastrectomy site, Lauren classification, and TD.

Source:

Wang, Q., Liu, Z., Han, J., Gao, Y., Shao, Y., Cai, H., & Yin, K. (2024). Vessel invasion is a risk factor for gastric cancer: a retrospective analysis study. In World Journal of Surgical Oncology (Vol. 22, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s12957-024-03604-1