IV Gentamicin reduces overall UTI risk in children with neurogenic bladder: Study
Without increasing the development of bacterial resistance to gentamicin, intravesical gentamicin instillation reduces the overall risk of urinary tract infections (UTI) and asymptomatic infections in children with neurogenic bladder (NGB), says an article published in the Journal of Pediatric Urology.
Children with neurogenic bladder who have recurrent UTIs have a higher risk of urosepsis and end-stage renal disease-related morbidity and death (ESRD). Intravesical gentamicin instillation has also been used to prevent these recurrences because low-dose prophylactic antibiotics have become less effective since the onset of extended-spectrum beta-lactamase (ESBL) organisms, but there is little information about its use in children in the literature. In order to compare the effectiveness of intravesical gentamicin instillation with oral antibiotic prophylaxis and assess its impact on microorganisms' antibiotic resistance, Manal Mouhssine and colleagues did this study.
This study involved 17 NGB children who were cared for at a tertiary facility and was retrospective in nature. The first term of oral antibiotic prophylaxis was followed by an intravenous injection of gentamicin. For each kid, a matched comparison of the frequency of UTIs, the detected bacteria, and their susceptibility to antibiotics was carried out in a conditional negative binomial regression model.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.