Mediterranean diet may halt prostate cancer progression, Finds study

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2021-02-05 01:00 GMT | Update On 2021-02-05 06:11 GMT

According to recent research, it has been found out that the Mediterranean diet is associated with a lower risk of Gleason grade group progression in men on active surveillance, as published in the American Cancer Society Journal.

The Mediterranean diet (MD) may be beneficial for men with localized prostate cancer (PCa) on active surveillance (AS) because of its anti‐inflammatory, antilipidemic, and chemopreventive properties.

Hence, Justin R. Gregg and associates from the Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas conducted this study to prospectively investigate the adherence to the MD with Gleason score progression and explored associations by diabetes status, statin use, and other factors.

The authors assessed a total of 410 men with newly diagnosed PCa on an AS protocol and the MD score was calculated across 9 energy‐adjusted food groups. Cox proportional hazards models were fit to evaluate multivariable‐adjusted associations of the MD score with progression‐free survival; progression was defined as an increase in the Gleason grade group (GG) score over a biennial monitoring regimen. In this cohort, 15% of the men were diabetic, 44% of the men used statins, and 76 men progressed

The key findings were-

a. Higher adherence to the MD was associated with a lower risk of GG progression among all men (hazard ratio [HR] per 1‐unit increase in MD score, 0.88; 95% confidence interval [CI], 0.77‐1.01), non‐White men (HR per 1‐unit increase in MD score, 0.64; 95% CI, 0.45‐0.92; P for interaction = .07), and men without diabetes (HR per 1‐unit increase in MD score, 0.82; 95% CI, 0.71‐0.96; P for interaction = .03).

b. When joint effects of the MD score and statin use were examined, a similar risk reduction was observed among men with high MD scores who did not use statins in comparison with men with low/moderate MD scores with no statin use.

Therefore, the authors concluded that "The MD is associated with a lower risk of GG progression in men on AS, and this is consistent with prior reports about the MD and reduced cancer morbidity and mortality."

Article Source : American Cancer Society Journal

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Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

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Mediterranean diet may halt prostate cancer progression, Finds study

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