Micronized Amnion/Chorion Bilayer Injections benefits Refractory Interstitial Cystitis/Bladder Pain Syndrome patients: Study
A recent groundbreaking study revealed that an amnion/chorion (AC) bilayer product could treat interstitial cystitis/bladder pain syndrome (IC/BPS) which normally does not respond to traditional treatments as per the results published in the journal International Urology & Nephrology.
Intravesical application of the birth tissue like amnion and chorion inside the bladder can reduce inflammation, reduce the development of excessive collagen formation, and help in the regeneration of healthy bladder tissue. Research in the past has shown that micronized (finely ground) amnion monolayer injections given to the bladder tissue have given temporary relief for IC/BPS patients who haven’t responded to traditional treatments. Hence, researchers from Wayne State University School of Medicine, Detroit, MI, USA conducted a study to evaluate the therapeutic responses and adverse events of micronized amnion/chorion bilayer (AC) in patients with refractory IC/BPS and followed up for 6 months.
About 15 IC/BPS patients, who did not respond to conventional treatments were included in the study. Each participant received about 100 mg of reconstituted micronized AC injections directly into the detrusor muscle layer by the cystoscopy method. The procedure was carried out under general anesthesia by using a 23-gauge needle. About twenty 0.5 mL injections were given across the lateral and posterior walls of the bladder avoiding certain areas of the bladder like the dome and trigone. The outcomes involved measuring Changes in interstitial cystitis symptom index (ICSI), Interstitial cystitis problem index (ICPI), Bladder pain/ interstitial cystitis symptom score (BPIC-SS), and Overactive Bladder Assessment Tool (OAB), from baseline to 6 months post-injection. A retrospective assessment of these changes was done and the safety of the injections was also analyzed.
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