No negative impact of Paracetamol use on semen quality of young men: Danish Study

Published On 2021-11-27 03:30 GMT   |   Update On 2021-11-27 06:25 GMT

Paracetamol (acetaminophen) is a common over-the-counter painkiller with hormone disruptive effects. There is little epidemiological evidence on the effect of paracetamol on male fecundity.

According to a new research undertaken by Cecilie Schmidt Stergaard and colleagues, there is no significant negative effect of paracetamol usage on semen quality in this sample of young Danish males. The consequences of high-dose and regular usage, on the other hand, cannot be ruled out. The findings of this study were published in Andrology journal on 15th November, 2021.

The objective of this study was to see if using paracetamol as an oral non-prescription moderate painkiller was related to sperm quality in young males. The data for this cross-sectional investigation came from the Fetal Programming of Semen Quality (FEPOS; 2017–2019) cohort of 1,058 young males (18–21 years) in the Danish National Birth Cohort.

Participants filled out a detailed online questionnaire on their health behaviors, including painkiller usage, and gave a sperm sample. The percentage differences (adjusted mean ratios (aMR)) in semen quality features were estimated using negative binomial regression models based on paracetamol usage (no; yes) and frequency of use (Almost never; 1/month; 1/month; 1/week).

The results stated as follows; in all, 28 percent of the 913 individuals having data reported using paracetamol in the previous six months. We discovered that users had a slightly greater total sperm count than non-users, but other sperm parameters were unchanged. The frequency of usage was associated with a reduced total sperm count and morphologically normal sperm cells, mainly among users 1/week; nevertheless, the confidence intervals were broad.

Advertisement

In conclusion, from the findings of this study it is advisable for the young men to restrain from frequent use of paracetamol specially at high doses. However further studies is needed to validate the above effects completely.

Reference:

Østergaard, C. S., Ernst, A., Gaml‐Sørensen, A., Brix, N., Toft, G., Hærvig, K. K., Hougaard, K. S., Bonde, J. P., Tøttenborg, S. S., & Ramlau‐Hansen, C. H. (2021). Use of paracetamol (acetaminophen) as a non‐prescription analgesic and semen quality in young men ‐ a cross‐sectional study. In Andrology. Wiley. https://doi.org/10.1111/andr.13129

Tags:    
Advertisement
Article Source : Andrology

Disclaimer: This site is primarily intended for healthcare professionals. Any content/information on this website does not replace the advice of medical and/or health professionals and should not be construed as medical/diagnostic advice/endorsement or prescription. Use of this site is subject to our terms of use, privacy policy, advertisement policy. © 2020 Minerva Medical Treatment Pvt Ltd

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Similar News