Sacral Neuromodulation device may be retained by overactive bladder patients with over 75% symptoms improvement

Therefore, David K Charles and colleagues from the Department of Urologic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA carried out the present study with the objective to determine if the degree of improvement after SNM-I is sufficient to predict long-term success.

The records of all patients who underwent sacral neuromodulation (SNM) for overactive bladder were reviewed. Subjects were divided into those who reported 50%-75% improvement (Group 1) and more than 75% improvement (Group 2) after SNM-I. Differences in clinical variables and long-term device efficacy were compared between groups.

The following findings are revealed-

a. Of 213 patients who underwent SNM-I, 137 underwent permanent device implantation.

b. A total of 76 (55%) and 61 (45%) patients reported 50%-75% (Group 1) and more than 75% (Group 2) symptomatic improvement, respectively.

c. With a mean follow-up of 46 months, 44% of Group 1 patients and 68% of Group 2 patients still had a functioning device providing the symptomatic benefit (p = 0.007).

d. Univariate analyses identified the presence of stress urinary incontinence at baseline and having a more than 75% improvement after SNM-I as predictors of long-term functional success.

Hence, the authors concluded that "Compared to patients reporting 50%-75% symptomatic reduction after SNM-I, individuals with a more than 75% improvement during SNM-I were more likely to maintain device efficacy over time."

However, additional study is warranted to determine if the improvement threshold for progression to SNM-II should be increased.