Underfilled or overfilled bladder associated with reduced detrusor contractility in bladder outlet obstruction in men

France: French researchers revealed the mechanisms of urinary retention in men with bladder outlet obstruction. They found from a study that reduced contractility was noticed when the bladder was under or overfilled. The study results were published in the journal Neurourology and Urodynamics. 

Urinary retention and voiding dysfunction are some of the lower urinary tract disorders occurring due to bladder outlet obstruction and impaired detrusor contractility. Bladder outlet obstruction is a progressive detrusor contractility alteration causing urinary retention. As there is not much literature on the relationship between detrusor contractility and bladder filling volume in men with lower urinary tract disorders, French researchers conducted a study to evaluate the impact of bladder filling volume on detrusor contractility in case of bladder outlet obstruction in men. 

A prospective multicenter study was carried out in two pelviperineology departments from January to July 2022. Eligible male patients indicated for urodynamics with an IPSS score > 7 were included. Participants with the absence of bladder outlet obstruction in pressure-flow studies were secondarily excluded. The primary endpoint was the maximum isometric detrusor pressure during a stop-test, corresponding to detrusor contractility, measured at 3 filling volumes (50%, 75%, and 100% of cystometric capacity).