Dupilumab safe to continue during vaccine administration in children with AD reveals study

Key findings from the study are:

• Nine children had severe AD at baseline.
• Five of the nine children received the MMR or MMR and varicella vaccines within a 1-7 week gap after their dupilumab administration, with treatment resuming for one child as early as two days and three children after 18-43 days.
• No serious adverse events were reported during a post-vaccination period in any children.

Concluding further, they said, In this case, a series of nine children with severe AD who received the MMR vaccine with or without varicella vaccine while being treated with dupilumab, no adverse events or infection were reported within four weeks of vaccination. Further studies are needed to investigate safety and immune response to live attenuated vaccines in dupilumab-treated patients

Sanofi and Regeneron Pharmaceuticals Inc. sponsored the study.

Reference:

Siegfried et al. A case series of live attenuated vaccine administration in dupilumab‐treated children with atopic dermatitis. Pediatric Dermatology.