Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • Medical Jobs
  • Medical Matrimony
  • MD Brand Connect
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • MCI News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Aborad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • MCI News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Anesthesia
  • Anesthesia News
  • Gabapentinoids have no...

Gabapentinoids have no analgesic effect on postoperative acute pain

MD BureauWritten by MD Bureau Published On 2021-01-12T02:03:11+05:30  |  Updated On 11 Jan 2021 8:33 PM GMT
Gabapentinoids have no analgesic effect on postoperative acute pain
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • koo
  • Email

Gabapentinoids, a class of drugs including gabapentin and pregabalin, was originally marketed in the 1990s for use as anticonvulsants and subsequently approved to treat specific chronic neuropathic pain conditions. Over the last decade, the off-label use of gabapentinoids for the control of acute nociceptive or neuropathic pain has drastically increased in several countries, and they are...

Gabapentinoids, a class of drugs including gabapentin and pregabalin, was originally marketed in the 1990s for use as anticonvulsants and subsequently approved to treat specific chronic neuropathic pain conditions. Over the last decade, the off-label use of gabapentinoids for the control of acute nociceptive or neuropathic pain has drastically increased in several countries, and they are now routinely used for the management of postoperative analgesia to decrease pain and opioid use. 

A recent study suggests that use of gabapentinoids does not yield a significant decrease in postoperative acute pain in adults but is associated with higher rates of visual disturbance and dizziness and longer length of hospital stay. The research has been published in the journal ANESTHESIOLOGY on August 2020.

The scientific data supporting the increased use of Gabapentinoids in a perioperative setup are divergent, which may reflect clinical agnosticism rather than new evidence of clinical effectiveness. Recommendations concerning the use of gabapentinoids for the management of postoperative pain are inconsistent. The American Pain Society (Glenview, Illinois) supports the perioperative use of gabapentinoids, while the European Society of Regional Anaesthesia and Pain Therapy (Geneva, Switzerland) does not. Recently, health authorities have raised serious concerns about potential adverse events (risk of abuse and respiratory depression) and net clinical benefit of gabapentinoids. Despite all this, the off-label use of gabapentinoids is still increasing worldwide. Therefore researchers of Canada conducted a systemic review and meta-analysis to evaluate the analgesic effect and adverse events with the perioperative use of gabapentinoids in adult patients.

It was a systemic review and meta-analysis of 281 clinical trials with 24,682 adult patients who underwent elective or emergent surgery. The major outcome assessed was the intensity of postoperative acute pain. Researchers also assessed the intensity of postoperative subacute pain, incidence of postoperative chronic pain, cumulative opioid use, persistent opioid use, lengths of stay, and adverse events as a secondary outcome.

Key findings of the study were:

• The researchers observed that gabapentinoids were associated with a lower postoperative pain intensity when compared with placebo at 6th,12th, 24th and 48th hour. However, they found the differences were not statistically significant ranging below the minimally important difference (10 points out of 100) for each time point.

• They found no difference in pain intensity between pregabalin and gabapentin.

• They also found that Gabapentinoids were not associated with the incidence of postoperative chronic pain.

• They noted Gabapentinoids slightly lower use of opioids at 24 hours (mean difference, −7.90 mg) and increases the length of hospital stay (mean difference, 2.96 hours).

• They reported less incidence of nausea/vomiting in Gabapentinoids group. However, they noted a significantly more visual disturbance (RR, 1.89) and dizziness (RR, 1.25)

The authors concluded, "No clinically significant analgesic effect for the perioperative use of gabapentinoids was observed. There was also no effect on the prevention of postoperative chronic pain and a greater risk of adverse events. These results do not support the routine use of pregabalin or gabapentin for the management of postoperative pain in adult patients".

For further information:

DOI: https://doi.org/10.1097/ALN.0000000000003428


Gabapentinoidsperioperative usejournal AnesthesiologyAnalgesic effectgabapentin and pregabalinPACT trial
Article Source :  ANESTHESIOLOGY
MD Bureau
MD Bureau

    Medical Dialogues Bureau consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers.  Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.

    Show Full Article
    Next Story
    Similar Posts
    NO DATA FOUND

    Editorial

    Journal Club Today

    Health News Today

    © 2022 All Rights Reserved.
    Powered By: Hocalwire
    X
    X