Blood urea nitrogen level may predict readmissions, mortality in HFpEF patients: Study

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-09-15T19:30:21+05:30 | Updated On 15 Sept 2022 7:30 PM IST

Japan: In a new study published in the International Journal of Cardiology, it was found that regardless of the renal function, blood urea nitrogen (BUN) was a meaningful measure for the composite of mortality and heart failure (HF) readmission and also was linked with left atrial function in HF with preserved ejection fraction (HFpEF) patients.

Blood urea nitrogen levels indicate a reduction in glomerular filtration rate (GFR). The influence of BUN on clinical outcomes in heart failure patients with maintained ejection fraction, excluding the effects of GFR, is uncertain. Masamichi Yano and colleagues undertook this study to assess the link between BUN and heart failure and its subtypes.

This prospective, multicenter research recruited HFpEF (50 percent left ventricular ejection fraction) patients hospitalized owing to acute decompensated heart failure from the PURSUIT-HFpEF registry. To rule out the influence of renal function on BUN levels, propensity score matching was used with factors related to GFR. The incidence of all-cause mortality and HF readmission among patients stratified by BUN, as well as the relationship between BUN and echocardiographic parameters in HFpEF patients, were investigated.

The key findings of this study were as follows:

1. This experiment had a total of 1029 subjects.

2. In this investigation, the BUN cut-off value was 24.4 mg/dL, which was also the median value in the whole population.

3. After 1:1 propensity score matching, the high and low BUN groups each included 193 patients.

4. The average period of follow-up was 401 days, and the composite endpoint occurred in 129 individuals (33.4% ).

5. In the propensity score-matched pairings, the high BUN group had a substantially higher risk of the composite endpoint than the low group.

6. Multiple regression analyses employing echocardiographic data revealed a substantial correlation between BUN and left atrial volume index.

In conclusion, according to the findings of this study, high BUN was related to the composite of all-cause mortality and HF readmission in HFpEF.

Reference:

Yano, M., Nishino, M., Ukita, K., Kawamura, A., Nakamura, H., Matsuhiro, Y., Yasumoto, K., Tsuda, M., Okamoto, N., Matsunaga-Lee, Y., Egami, Y., Tanouchi, J., … Sakata, Y. (2022). Clinical impact of blood urea nitrogen, regardless of renal function, in heart failure with preserved ejection fraction. In International Journal of Cardiology. Elsevier BV. https://doi.org/10.1016/j.ijcard.2022.06.061

International Journal of Cardiologyheart failureblood urea nitrogen

Source : International Journal of Cardiology

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751