- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
CKD predicts incomplete revascularization and subsequent MACE in CCS patients
Egypt: Chronic kidney disease predicts partial revascularization and subsequent major adverse cardiovascular events (MACE) in patients with chronic coronary syndrome (CCS), a recent study published in the Indian Heart Journal has revealed.
The study showed that among patients with CCS, chronic kidney disease (CKD) is associated with a higher syntax score (SS) and incomplete revascularization prevalence. Additionally, an association was observed between incomplete revascularization and an increased risk of MACE.
Atherosclerotic plaque formation in the epicardial coronary arteries is the pathological hallmark of coronary artery disease (CAD). Several clinical manifestations can be classified as either chronic coronary syndrome or acute coronary syndrome due to the dynamic nature of the CAD process.
Chronic kidney disease and coronary artery disease constitute a high-risk combination. Despite its high prevalence, few studies have been conducted on CAD, specifically in CKD patients, frequently excluded from most trials. Therefore, there is a lack of evidence for CAD management, which might lead to the inadequate treatment of CKD patients.
To fill this knowledge gap, Shereen Ibrahim Farag, Benha University, Faculty of Medicine, Cardiology Department, Benha, Egypt, and colleagues aimed to determine the impact of CKD on the completeness of revascularization and MACE in patients with chronic coronary syndrome.
The study enrolled 400 patients with CCS who underwent revascularization by PCI. They were categorized into two categories according to their estimated glomerular filtration rate (eGFR) levels: the control group: 200 patients with eGFR ≥60mL/min/1.73m2, and the CKD Group: 200 patients with eGFR< 60ml/min/1.73m.
Reclassification of the patients was done according to revascularization into complete and incomplete revascularization groups with a one-year follow-up to assess the MACE.
Based on the study, the researchers reported the following findings:
- CKD patients were significantly older (65.78 ± 6.41 versus 56.70 ± 9.20 years). They had higher contrast-induced nephropathy, syntax scores, all-cause mortality, heart failure, and MACE.
- After reclassification according to revascularization, GFR was significantly reduced among patients with incomplete revascularization (51.08 ± 28.15 versus 65.67 ± 26.62, respectively).
- Repeated revascularization, stent thrombosis, STEMI, MACE, stroke, and all-cause mortality were more prevalent among patients with incomplete revascularization.
- Multivariate regression analysis revealed eGFR and SS as independent predictors of incomplete revascularization.
- The optimal eGFR cutoff value for predicting partial revascularization is 49.50mL/min/1.73m2, with 58.8% sensitivity and 69.3 % specificity.
"The findings showed that chronic kidney disease is linked with a higher prevalence of syntax score and incomplete revascularization in CCS patients," the researchers wrote.
"Incomplete revascularization is also related to a higher prevalence of MACE. As a result, CKD predicts incomplete revascularization and subsequent MACE in CCS patients," they concluded.
Reference:
Farag, S. I., Mostafa, S. A., Kabil, H., & Elfaramawy, M. R. (2023). Chronic kidney disease's impact on revascularization and subsequent major adverse cardiovascular events in patients with chronic coronary syndrome. Indian Heart Journal. https://doi.org/10.1016/j.ihj.2023.11.006
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751