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  • Dapagliflozin may...

Dapagliflozin may reduce atrial fibrillation/flutter in diabetes patients: Circulation

Medha BaranwalWritten by Medha Baranwal Published On 2020-02-09T11:15:12+05:30  |  Updated On 2020-02-09T11:15:19+05:30
Dapagliflozin may reduce atrial fibrillation/flutter in diabetes patients: Circulation

Delhi: SGLT2 inhibitor dapagliflozin reduced the incidence of reported episodes of atrial fibrillation/atrial flutter (AF/AFL) adverse events in high-risk patients with type 2 diabetes, according to a recent study published in the AHA journal Circulation. This effect was consistent regardless of the patients' prior history of AF, ASCVD, or HF (heart failure).Atrial fibrillation and atrial...

Delhi: SGLT2 inhibitor dapagliflozin reduced the incidence of reported episodes of atrial fibrillation/atrial flutter (AF/AFL) adverse events in high-risk patients with type 2 diabetes, according to a recent study published in the AHA journal Circulation. This effect was consistent regardless of the patients' prior history of AF, ASCVD, or HF (heart failure).

Atrial fibrillation and atrial flutter are associated with diabetes and its comorbidities include heart failure, obesity and hypertension. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been shown to have multiple favourable effects including reductions in heart failure and kidney failure in a broad population of patients. Stephen D. Wiviott, Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, and colleagues, therefore, hypothesized that SGLT2i may reduce the risk of AF/AFL.

The researchers conducted a posthoc analyses of a the DECLARE-TIMI 58 trial, which tested dapagliflozin against placebo in more than 17,000 patients with type 2 diabetes and atherosclerotic cardiovascular disease or multiple risk factors for such disease. In the present study, they explored the effect of dapagliflozin on the first and total number of AF/AFL events in patients with (n=1,116) and without prevalent AF/AFL using Cox and negative binomial models, respectively

Key findings of the study include:

  • Dapagliflozin reduced the risk of AF/AFL events by 19% (264 versus 325 events, 7.8 versus 9.6 events per 1000 patient-years, hazard ratio 0.81).
  • The reduction in AF/AFL events was consistent regardless of the presence or absence of a history of AF/AFL at baseline (Prior AF/AFL: HR 0.79, No AF/AFL: HR 0.81).
  • The presence of ASCVD (HR 0.83) versus MRF (HR 0.78), or a history of HF (HF: HR 0.78, No HF: HR 0.81) did not modify the reduction in AF/AFL events observed with dapagliflozin.
  • There was no effect modification by sex, history of ischemic stroke, HbA1c, body mass index, blood pressure, or Egfr.
  • Dapagliflozin also reduced the total number (first and recurrent) of AF/AFL events (337 versus 432; incidence rate ratio 0.77).

"The new findings for the first time "suggest that there may be an additional benefit of SGLT2i in reducing new and recurrent atrial fibrillation," wrote the authors.

The study, "Effect of Dapagliflozin on Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus: Insights from the DECLARE-TIMI 58 Trial," is published in the journal Circulation.

DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.044183

atrial fibrillation atrial flutter SGLT2 inhibitor Circulation dapagliflozin diabetes sodium-glucose transport proteins 
Source : journal Circulation
Medha Baranwal
Medha Baranwal

    MSc. Biotechnology

    Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751

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