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Flu vaccination after heart attack should become standard care, study suggests
Findings suggest that influenza vaccination should be considered as part of in-hospital treatment after myocardial infarction.
Delhi: In-hospital influenza vaccination after myocardial infarction or high-risk coronary disease reduces the risk of all-cause death, myocardial infarction, or stent thrombosis at 12 months, show results from a recent study.
The findings of the study were presented at the ESC Congress 2021 and subsequently published in the journal Circulation.
During influenza epidemics, more people die from cardiovascular causes than during non-epidemic periods.2 Observational studies have suggested a protective effect from influenza vaccination on cardiovascular events, and single-center randomized trials have supported these findings.3-5 Influenza vaccination is recommended for patients with heart disease but is not part of standard hospital care following an acute myocardial infarction.
The IAMI trial was the largest randomized trial to date to evaluate whether influenza vaccination improves outcomes following myocardial infarction or percutaneous coronary intervention in high-risk patients with coronary artery disease. The trial was conducted at 30 hospitals in eight countries (Sweden, Denmark, Norway, Latvia, the UK, Czech Republic, Bangladesh, and Australia) over four influenza seasons spanning October 2016 through February 2020.
Participants were randomly assigned in a 1:1 ratio to receive either the influenza vaccine or placebo within 72 hours of an invasive coronary procedure or hospitalization. The primary endpoint was a composite of all-cause death, myocardial infarction, or stent thrombosis at 12 months. A hierarchical testing strategy was used for the key secondary outcomes of all-cause death, cardiovascular death, myocardial infarction, and stent thrombosis.
The trial was halted prematurely on 7 April 2020 by the data safety and monitoring board due to the COVID-19 pandemic after the enrolment of 2,571 patients (58% of the target). The average age of participants was 60 years and 18% were women.
The primary composite endpoint occurred in 67 patients (5.3%) in the vaccine group and 91 (7.2%) in the placebo group (hazard ratio [HR] 0.72). Regarding secondary endpoints, death from any cause occurred in 37 patients (2.9%) in the vaccine group and 61 (4.9%) in the placebo group (HR 0.59). Rates of cardiovascular death were 2.7% and 4.5%, respectively (HR 0.59). There was no difference between groups in the rate of myocardial infarction, which occurred in 25 (2.0%) and 29 (2.4%) patients in the vaccine and placebo groups, respectively (HR 0.86).
Serious adverse events were rare and of similar type and incidence in both groups. injection site reactions like pain, redness, swelling, and hardening were reported significantly more often in patients assigned to influenza vaccine.
Principal investigator Professor Ole Fröbert of Örebro University, Sweden said: "The IAMI trial found that in patients with myocardial infarction or high-risk coronary disease, early influenza vaccination resulted in a lower risk of the composite of all-cause death, myocardial infarction or stent thrombosis at 12 months compared with placebo. Our findings suggest that influenza vaccination should be considered as part of in-hospital treatment after myocardial infarction."
Reference:
The study titled, "Influenza Vaccination after Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial," is published in the journal Circulation.
DOI: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057042
Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751