High and low HDL-C increases risk of CV events among men with hypertension

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-08-20T12:00:47+05:30 | Updated On 20 Aug 2022 12:47 PM IST

Italy: A new study conducted by Valentina Trimarco and colleagues showed that HDL-C (high-density lipoprotein cholesterol) and the risk of cardiovascular events in male hypertensive patients are related. The findings of this study were published in Hypertension.

High levels of HDL-C may be associated with a higher risk of death, according to recent research. To the best of our knowledge, no research has ever been done on individuals with hypertension on the association between HDL-C and certain cardiovascular events. Therefore, the purpose of this study was to describe the part HDL-C plays in all types of cardiovascular events.

Researchers examined the connection between HDL-C levels and cardiovascular events in hypertensive individuals within the Campania Salute Network in Southern Italy to close this knowledge gap.

The key findings of this study were:

1. During a 25 534 person-year period, 11 987 people with hypertension were identified and monitored.

2. According to the plasma HDL-C levels, the population was split into three groups: low HDL-C (HDL-C<40 mg/dL), medium HDL-C (HDL-C between 40 and 80 mg/dL), and high HDL-C (HDL-C >80 mg/dL) (high HDL-C).

3. A total of 245 cardiovascular events were noted at the follow-up analysis after possible confounders were taken into account, with the low HDL-C group and the high HDL-C arm having a considerably higher risk of cardiovascular events than the medium HDL-C group.

4. A nonlinear U-shaped connection between HDL-C levels and cardiovascular outcomes was found by the spline analysis. It's interesting to note that female patients did not experience the elevated cardiovascular risk linked with high HDL-C.

In conclusion, the findings of this study fill a critical knowledge gap in the field: HDL-C levels are currently taken into account as a protective factor in algorithms used to estimate cardiovascular risk in the general population, but at very high levels, this protective effect does not appear to hold true and may even increase risk. In female subjects, the increased cardiovascular risk linked to high HDL-C levels was not confirmed. Notably, one should take into account the low number of occurrences, which results in less accurate estimations when compared to the whole cohort (particularly in the female cohort).

Reference:

Trimarco, V., Izzo, R., Morisco, C., Mone, P., Maria Virginia, M., Falco, A., Pacella, D., Gallo, P., Lembo, M., Santulli, G., & Trimarco, B. (2022). High HDL (high-density lipoprotein) cholesterol increases cardiovascular risk in hypertensive patients. Hypertension.https://doi.org/10.1161/HYPERTENSIONAHA.122.19912

HDL cholesterolhypertensionAmerican Heart Associationcardiovascular disease

Source : Hypertension journal

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751