High In-hospital glycemic variability Independent Predictor of 1-yr Mortality in Acute HF Patients

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-01-04T09:00:26+05:30 | Updated On 4 Jan 2023 12:37 PM IST

High In-hospital glycemic variability (GV) is an Independent Predictor of 1-yr Mortality in Acute HF Patients suggests a recent study published in the Cardiovascular Diabetology.

High glycemic variability (GV) is a poor prognostic marker in cardiovascular diseases. We aimed to investigate the association of GV with all-cause mortality in patients with acute heart failure (HF).

The Korean Acute Heart Failure registry enrolled patients hospitalized for acute HF from 2011 to 2014. Blood glucose levels were measured at the time of admission, during hospitalization, and at discharge. They included those who had 3 or more blood glucose measurements in this study. Patients were divided into two groups based on the coefficient of variation (CoV) as an indicator of GV. Among survivors of the index hospitalization, we investigated all-cause mortality at 1 year after discharge.

Results

• The study analyzed 2,617 patients (median age, 72 years; median left-ventricular ejection fraction, 36%; 53% male).

• During the median follow-up period of 11 months, 583 patients died. Kaplan–Meier curve analysis revealed that high GV (CoV > 21%) was associated with lower cumulative survival

• Multivariate Cox proportional analysis showed that high GV was associated with an increased risk of 1-year mortality.

• High GV significantly increased the risk of 1-year mortality in non-diabetic patients but not in diabetic patients

• High in-hospital GV before discharge was associated with all-cause mortality within 1 year, especially in non-diabetic patients with acute HF.

Reference:

Chun, KH., Oh, J., Lee, C.J. et al. In-hospital glycemic variability and all-cause mortality among patients hospitalized for acute heart failure. Cardiovasc Diabetol 21, 291 (2022). https://doi.org/10.1186/s12933-022-01720-4

Keywords:

Glucose metabolism disorder, Glycemic variability, Type 2 diabetes mellitus, Heart failure, Cardiovascular Diabetology, Chun, KH., Oh, J., Lee, C.J.

Cardiovascular DiabetologyGlucose metabolism disorderGlycemic variabilityType 2 diabetes mellitusHeart failure

Source : Cardiovascular Diabetology

Dr. Shravani Dali

Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751