High ratio of fasting blood sugar to HDL-C tied to CV adverse events, death in ACS patients: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-02-26T09:00:41+05:30 | Updated On 26 Feb 2022 9:01 AM IST

China: A recent study reveals that a higher ratio of fasting blood glucose to high-density lipoprotein cholesterol (FG/HDL-C) is tied to a higher risk of MACEs and CV death in acute coronary syndrome (ACS) patients. The study appears in the BMC journal Lipids in Health and Disease on 30 January 2022.

Biochemical markers are critical for determining risk in patients with coronary artery disease (CAD); however, there is no clarity on the relationship between FG/HDL-C ratio and short-term outcomes in ACS patients. Therefore, Xinqun Hu, Central South University, Changsha, Hunan, China, and colleagues aimed to investigate the relationship between the FG/HDL-C ratio and short-term outcomes in ACS patients.

For this purpose, the researchers performed a post hoc analysis using data from a pragmatic, stepped-wedge, cluster-randomized clinical trial. 11,284 individuals with ACS were subdivided into quartiles in accordance with their FG/HDL-C ratios.

The relationship between the FG/HDL-C ratio and short-term outcomes (major adverse cardiovascular events [MACEs] and cardiovascular [CV] death within 30 days) was evaluated using a multivariate logistic regression model, two-piecewise linear regression model, and generalized additive model (GAM).

Following were the main findings of the study:

· The FG/HDL-C ratio was remarkably linked to an enhanced risk of MACEs and CV death in individuals with ACS in the highest quartile (MACEs, odds ratio [OR]: 1.49; CV death, OR: 1.69).

· The GAM suggested that the relationship between the FG/HDL-C ratio and MACEs and CV death was non-linear.

· The two-piecewise linear regression model demonstrated that the threshold values were 3.02 and 3.00 for MACEs and CV death, respectively.

"The study showed that FG/HDL-C ratio may be used as an accessible, convenient, and economical biomarker of short-term outcomes in ACS patients," the authors concluded. "Close attention should be paid to ACS patients undergoing CABG and those aged < 75 years with a high FG/HDL-C ratio."

Reference:

Deng, S., Wang, Z., Zhang, Y. et al. Association of fasting blood glucose to high-density lipoprotein cholesterol ratio with short-term outcomes in patients with acute coronary syndrome. Lipids Health Dis 21, 17 (2022). https://doi.org/10.1186/s12944-021-01618-2

Lipids in Health and Diseaseblood sugaracute coronary syndromeHDL-C

Source : Lipids in Health and Disease

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751