individuals with genetic predisposition to low alcohol metabolism susceptible to incident AF after alcohol consumption

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-01-03T10:00:53+05:30 | Updated On 3 Jan 2024 1:35 PM IST

In a recent study found the relationship between alcohol consumption, genetic predisposition and the risk of incident atrial fibrillation (AF). The findings of this study were published in the BMC Medicine Journal.

The study encompassed 399,329 subjects from the database of UK Biobank who were enrolled from 2006 to 2010. The study utilized genetic data to explore the interplay between alcohol consumption and AF risk. The participants were followed until 2021 with the genetic predisposition to alcohol metabolism stratified based on polygenic risk score (PRS) tertiles.

During the median follow-up of 12.2-year, a total of 19,237 cases of AF was observed. The data revealed a significant association between genetic predisposition to alcohol metabolism and actual alcohol consumption habits (P < 0.001). Mild-to-moderate drinkers expressed a decreased risk of AF (HR 0.96, 95% CI 0.92–0.99), while heavy drinkers faced an increased risk (HR 1.06, 95% CI 1.02–1.10) compared to non-drinkers.

After stratifying the results according to PRS tertiles uncovered that mild-to-moderate drinkers had equivalent AF risks across all PRS tertiles, while the heavy drinkers expressed increased AF risk in the low PRS tertile group. In the middle/high PRS tertile groups the mild-to-moderate drinkers experienced reduced AF risks and heavy drinkers faced similar risks.

The findings highlight the critical interplay between alcohol consumption, genetic predisposition to alcohol metabolism and the risk of incident AF. The individuals with a genetic predisposition to low alcohol metabolism were observed to be more susceptible to AF by highlighting personalized risk factors for this common cardiac condition.

Source:

Park, C. S., Choi, J., Choi, J., Lee, K.-Y., Ahn, H.-J., Kwon, S., Lee, S.-R., Choi, E.-K., Kwak, S. H., & Oh, S. (2023). Risk of newly developed atrial fibrillation by alcohol consumption differs according to genetic predisposition to alcohol metabolism: a large-scale cohort study with UK Biobank. In BMC Medicine (Vol. 21, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s12916-023-03229-3

BMC MedicineAlcohol metabolismatrial fibrillation

Source : BMC Medicine

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751