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  • Non-vitamin K...

Non-vitamin K antagonist oral anticoagulants associated with lower risks of bone fracture, Finds study

Written By : Dr. Nandita Mohan |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-04-22T06:45:05+05:30  |  Updated On 22 April 2021 12:58 PM IST
Non-vitamin K antagonist oral anticoagulants associated with lower risks of bone fracture, Finds study
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According to recent research, it has been found that when compared with warfarin, non-vitamin K antagonist oral anticoagulants (NOACs) are associated with lower risks of bone fracture, as published in the Journal of American Heart Association.

Evidence on the differences in fracture risk associated with non‐vitamin K antagonist oral anticoagulants (NOAC) and warfarin is inconsistent and inconclusive.

Therefore, Huei‐Kai Huang and colleagues from the Institute of Epidemiology and Preventive Medicine, , College of Public Health, , National Taiwan University, Taipei, Taiwan conducted the a systematic review and meta‐analysis to assess the fracture risk associated with NOACs and warfarin.

The authors included studies presenting measurements (regardless of primary/secondary/tertiary/safety outcomes) for any fracture in both NOAC and warfarin users. Two or more reviewers independently screened relevant articles, extracted data, and performed quality assessments. Data were retrieved to synthesize the pooled relative risk (RR) of fractures associated with NOACs versus warfarin. Random‐effects models were used for data synthesis. A total of 29 studies (5 cohort studies and 24 randomized controlled trials) with 388 209 patients were included for the present study.

The results seen were-

  1. Patients treated with NOACs had lower risks of fracture than those treated with warfarin (pooled RR, 0.84; 95% CI, 0.77–0.91; P<0.001) with low heterogeneity (I2=38.9%).
  2. NOACs were also associated with significantly lower risks of hip fracture than warfarin (pooled RR, 0.89; 95% CI, 0.81–0.98; P=0.023).
  3. A nonsignificant trend of lower vertebral fracture risk in NOAC users was also observed (pooled RR, 0.74; 95% CI, 0.54–1.01;
    P
    =0.061).
  4. Subgroup analyses for individual NOACs demonstrated that dabigatran, rivaroxaban, and apixaban were significantly associated with lower fracture risks.

Furthermore, the data synthesis results from randomized controlled trials and real‐world cohort studies were quite consistent, indicating the robustness of our findings, the researchers revealed.

Hence, it was concluded that "compared with warfarin, NOACs are associated with lower risks of bone fracture."


Non‐vitamin K antagonistoral anticoagulantslower risksbone fractureJournal of American heart association
Source : Journal of American Heart Association
Dr. Nandita Mohan
Dr. Nandita Mohan

    Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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