PET technology effectively determines need for CABG or PCI in subendocardial ischemia

USA: A research team from UTHealth Houston Heart & Vascular have shown that a new method for determining whether heart disease patients require coronary stents or bypass surgery is more effective than the currently used angiogram.

The researchers used PET (positron emission tomography) imaging technology to map coronary blood flow and its outcomes:- subendocardial ischemia in patients with heart disease. The study, published in JACC: Cardiovascular Imaging, was conducted by a team led by K. Lance Gould, MD, professor and the Martin Bucksbaum Distinguished University Chair in Heart Disease with McGovern Medical School at UTHealth Houston.

Most forms of heart disease cause myocardial damage. Myocardial ischemia occurs when blood flow to the heart is reduced, preventing the heart muscle from receiving enough oxygen. When myocardial ischemia affects the deep, or subendocardial, a layer of the left ventricular muscle, it is known as subendocardial ischemia.

Subendocardial ischemia is commonly diagnosed in patients with cardiovascular disease, but current imaging tools do not quantify it. Gould's team developed PET technology, software, and clinical validation for defining the size and severity of this early stage of coronary artery disease.

"The cumulative data reveals that all randomized trials of coronary stents and bypass surgery have failed to improve survival after revascularization due to profoundly flawed patient selection based on the angiogram," said Gould, the first author of the study. "Thus, the coronary angiogram is not the gold standard for determining stents or bypass surgery, but rather, quantitative myocardial perfusion by PET is the gold standard."

Significantly, the paper confirmed the team's previous research by proving the PET threshold of severity at which stents and bypass surgery improve survival compared to medical treatment alone. The angiogram-an X-ray test that helps doctors evaluate blockages in the arterial system, shows how to do stents or bypass surgery, Gould said, but not whether those procedures should be done at all.

Gould, who began working at UTHealth Houston in 1979 as a professor and director of the division of cardiology, stepped aside from administrative duties in 1987 to focus clinically and scientifically on PET imaging and quantitative coronary arteriography for identifying segmental and diffuse coronary artery disease, measuring its severity and reversing it by vigorous risk factor modification.

"Several equally paradigm-changing papers are underway for the coming year," Gould said. "For example, our preliminary data show that virtual revascularization on cardiac PET images predicts survival outcomes before actually doing stents or bypass surgery, as a guide to making decisions for or against those procedures."

Reference:

K. Lance Gould, Tung Nguyen, Richard Kirkeeide, Amanda E. Roby, Linh Bui, Danai Kitkungvan, Monica B. Patel, Mohammad Madjid, Mary Haynie, Dejian Lai, Ruosha Li, Jagat Narula, Nils P. Johnson, Subendocardial and Transmural Myocardial Ischemia: Clinical Characteristics, Prevalence, and Outcomes With and Without Revascularization, JACC: Cardiovascular Imaging, 2022, https://doi.org/10.1016/j.jcmg.2022.05.016.