Triglyceride glucose index strongly linked to HFpEF in patients with hypertension
China: In heart failure with preserved ejection fraction (HFpEF) patients, the triglyceride glucose index (TyG index) index is higher than in non-HFpEF patients and is related to cardiac diastolic function. This strongly correlated with the occurrence of HFpEF in hypertensive patients. These are the results from a recent study published in the journal Clinical Cardiology.
TyG index is a novel marker of insulin resistance. Previous studies have shown that the TyG index is closely related to the occurrence of cardiovascular disease and hypertension. However, not much is known about the correlation between the TyG index and the occurrence of HFpEF in patients with hypertension.
Against the above background, Li Ping Liao, Shanghai Jiao Tong University School of Medicine, Shanghai, China, and colleagues assumed that the TyG index strongly correlates with the occurrence of HFpEF in hypertensive patients.
The researchers enrolled 559 hypertensive patients (273 patients with HFpEF and 286 without HFpEF) as the study subjects. Recording to age, gender, diastolic blood pressure, systolic blood pressure (SBP), and heart rate (HR) was done at admission. After admission to detect laboratory index, medication history and fasting blood samples were harvested. Echocardiography was used to measure cardiac function and ventricular structure index.
To identify the correlation of the TyG index with cardiac function and ventricular structure, a Pearson correlation analysis was conducted. The diagnostic value of the TyG index in HFpEF with hypertension was evaluated using the receiver operating characteristic (ROC) curve.
The study led to the following findings:
- HFpEF patients had higher diuretic use frequencies, fasting plasma glucose, NT-proBNP, triglycerides, TyG index, left atrial diameter (LAD), left ventricular mass index (LVMI), the ratio of peak E-velocity of the mitral orifice to peak velocity of the early diastolic mitral annulus (E/e′), and SBP but a lower ratio of peak E of early diastolic maximum blood flow velocity to peak A of the late diastolic maximum blood flow velocity of the mitral orifice (E/A) and average e′ than non-HFpEF patients.
- TyG index was correlated with LAD, left ventricular ejection fraction (LVEF), LVMI, average e′, E/e′, and NT-proBNP.
- The multivariate regression analysis suggested that TyG index, E/e′, and NT-proBNP were independent risk factors for HFpEF in hypertensive patients.
- Compared with E/e′ and NT-proBNP, the area under the ROC curve (0.778) was the largest for the TyG index.
To conclude, the study shows that the TyG index strongly correlates with the occurrence of HFpEF in hypertensive patients.
Reference:
Liao, Li Ping, et al. "Correlation Analysis of the Triglyceride Glucose Index and Heart Failure With Preserved Ejection Fraction in Essential Hypertensive Patients." Clinical Cardiology, 2022.
