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Ultra-Low-Temperature Cryoablation promising in Treatment of Ventricular Tachycardias: Study
A recent first-in-human clinical trial, Cryocure-VT, has unveiled an amazing advancement in the treatment of scar-dependent ventricular tachycardias (VTs). The trial investigated the safety and efficacy of a novel ultra-low-temperature cryoablation (ULTC) catheter system utilizing nitrogen cryogen at a chilling -196°C, showcasing remarkable potential in addressing this cardiac arrhythmia.
- Out of the 64 patients enrolled (with a mean age of 67 years and predominantly ischaemic etiology), ultra-low temperature cryoablation demonstrated impressive acute effectiveness, achieving the primary endpoint in 94% of cases where post-ablation induction was attempted.
- Importantly, the procedure exhibited an excellent safety profile, with no protocol defined MAEs reported. Even in cases where procedure-related serious adverse events occurred, they were promptly resolved without lasting clinical consequences.
- At the six-month follow-up, a significant proportion of patients remained free from VT, with a notable reduction in the burden of ventricular arrhythmias, particularly in those with prior implantable defibrillators.
- Notably, the efficacy of ULTC cryoablation was consistent across both ischaemic and non-ischaemic cardiomyopathy cohorts, underscoring its broad applicability in diverse patient populations.
- At 6-month follow-up, 60.3% remained VT-free, and freedom from ICD shock was 81.0%, with no significant difference between ischaemic and non-ischaemic cohorts.
BDS, MDS
Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.