Vitamin D insufficiency and inflammation in older adults tied to CVD risk: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-06-09T11:03:26+05:30 | Updated On 9 Jun 2022 11:03 AM IST

Brazil: The presence of inflammation and low concentrations of vitamin D is linked to a high risk for cardiovascular diseases in older adults, reveals a recent study published in Experimental Gerontology. Also, older adults with 25(OH)D insufficiency presented higher levels of fasting blood sugar.

Older adults with high hs-CRP concentration had a higher percentage of global risk for cardiovascular events over the next 10 years, the researchers reported. They also found a negative correlation between the biomarkers 25(OH) and hs-CRP.

The cross-sectional study was conducted by Nathalia Fidelis LinsVieira, Institute of Biological Sciences, Universidade de Pernambuco, Recife, Pernambuco, Brazil, and colleagues aimed to identify an association between serum levels of 25(OH) D, inflammation, and cardiovascular disease risk in older adults.

The study included older adults of both sexes. It investigated variables on anthropometric assessments (weight, height, waist circumference, BMI), lifestyle, and systemic arterial hypertension (systolic blood pressure, SBP, and diastolic blood pressure DBP), serum levels of 25(OH)D, serum high-sensitive C-reactive protein (hs-CRP), serum lipid profile and fasting blood glucose. Global risk for cardiovascular events, the Framingham criteria were used to assess cardiovascular disease risk.

The study led to the following findings:

The sample consisted of 124 participants, 50.8% of whom were at high risk for cardiovascular events.
Older adults with 25(OH)D insufficiency presented higher levels of blood sugar, LDL-c SBP, and hs-CRP.
When grouped by serum concentrations hs-CRP, it was observed that higher hs-CRP levels were associated with higher blood glucose, SBP, and lower HDL-c concentrations.
It was also observed that 25(OH)D insufficiency increased the chance of high risk for cardiovascular events by 2.8 times (OR = 2.80), which with high hs-CRP concentrations increased to 4.75 times (OR = 4.75).

The researchers conclude, "low concentrations of 25(OH)D and the presence of inflammation in older adults are associated with a high risk for cardiovascular diseases."

Reference:

Vieira, Nathalia Fidelis Lins, et al. "25-hydroxyvitamin D Insufficiency and Inflammation Increase Cardiovascular Risk in Older People." Experimental Gerontology, 2022, p. 111864.

cardiovascular diseasevitamin DinflammationExperimental Gerontology

Source : Experimental Gerontology

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751