Vitamin D supplementation improves dyslipidemia and insulin concentration in elderly: BMC
Iran: Findings from a meta-analysis suggest that vitamin D supplementation (VDS) could improve dyslipidemia and insulin concentration in the elderly population. This is particularly effective in short-term intervention duration and in patients with diabetes and vitamin D deficiency. The study appears in the BMC journal Diabetology & Metabolic Syndrome. The potential effect...
Iran: Findings from a meta-analysis suggest that vitamin D supplementation (VDS) could improve dyslipidemia and insulin concentration in the elderly population. This is particularly effective in short-term intervention duration and in patients with diabetes and vitamin D deficiency. The study appears in the BMC journal Diabetology & Metabolic Syndrome.
The potential effect of vitamin D in cardiac-metabolic disease prevention has been a topic of longstanding interest. However, the results regarding the impact of vitamin D supplementation on the management of cardiac-metabolic outcomes in the elderly have been divergent.
Given the critical assessment of the vitamin D impact on the elderly, Maryam Khazdouz, Tehran University of Medical Sciences, Tehran, Iran, and colleagues aimed to investigate the overall effects of VDS on cardiac-metabolic outcomes in the elderly population.
For this purpose, the researchers systematically searched the electronic databases. All trials that evaluated the effect of VDS on cardiac-metabolic risk factors in the elderly population were included. Standardized mean difference (SMD) was used to assess the effects of VDS on cardiac-metabolic outcomes.
Salient findings of the study include:
- The literature search identified 4409 studies, of which 12 trials met inclusion criteria.
- Results of random effect meta-analysis indicated a significant reduction in total cholesterol (TC) (SMD: − 0.14 mg/dl) and triglyceride (TG) (SMD: − 0.45 mg/dl) with VDS compared to the placebo.
- The subgroup analyses revealed that the reduction of TG in patients with diabetes and vitamin D deficiency was significant.
- Short-term intervention (≤ 6 months) induced a significantly lower level of TG and insulin in comparison to longer duration (> 6 months).
The researchers wrote, "our findings suggest that VDS may improve TG, TC, and insulin concentration in the elderly, especially in short-term intervention duration and in patients with vitamin D deficiency and diabetes.
However, they warn that the study results must be interpreted with caution given the high heterogeneity between included studies, and there is a need for larger and well-designed RCTs to validate these findings.
Qorbani, M., Zarei, M., Moradi, Y. et al. Effect of vitamin D supplementation on cardiac-metabolic risk factors in elderly: a systematic review and meta-analysis of clinical trials. Diabetol Metab Syndr 14, 88 (2022). https://doi.org/10.1186/s13098-022-00859-0
Medha, MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at firstname.lastname@example.org. Contact no. 011-43720751