BPLTTC: Using Antihypertensive agents as risk modifiers for prevention of CV events irrespective of baseline criteria: Scope of Amlodipine
Hypertension, a prominent cause of premature mortality, affects ~1.13 billion people worldwide, though blood pressure (BP) control rates remain dismal at <20%. (1) Though several trials have shown that BP-lowering with antihypertensive agents is an effective strategy for reducing cardiovascular (CV) risk, the treatment and control rates of patients with hypertension (BP>140/90 mm Hg) across the world remain disappointing.
This discrepancy can be partly attributed to the fact that ambiguities continue to exist about the efficacy and safety of BP-lowering. Some of the issues include the lack of expert consensus on the suitable BP threshold for initiation of therapy and whether this should vary based on the patient's age or baseline disease status. Similarly, data is frugal on the effects of antihypertensive therapy on safety and non- vascular outcomes. (2)