Breakthrough sepsis drug shows promise in human trial

Researchers at Griffith University report encouraging progress toward treating sepsis after a Phase II clinical trial in China produced positive results. The study suggests a new drug candidate may reduce the severity of sepsis, a condition that affects millions of hospitalized patients worldwide each year.

The experimental treatment, known as STC3141, is a carbohydrate-based drug developed through a collaboration between Distinguished Professor Mark von Itzstein AO and his team at Griffith's Institute for Biomedicine and Glycomics and Professor Christopher Parish and his team at The Australian National University.

"The trial met the key endpoints to indicate the drug candidate was successful in reducing sepsis in humans," Professor von Itzstein said.

How the Drug Works in the Body

During the trial, STC3141 was delivered through an infusion using a cannula. The drug was designed to counteract a major biological molecule release that occurs during sepsis, a process that can drive widespread inflammation and organ damage.

As a small-molecule experimental therapy, STC3141 may help treat sepsis by reversing damage to organs rather than only managing symptoms.

Why Sepsis Remains a Major Medical Challenge

Sepsis develops when the body's immune system overreacts to an infection and begins damaging its own tissues and organs. The condition is one of the leading causes of death and long-term disability worldwide.

"When sepsis is not recognized early and managed promptly, it can lead to septic shock, multiple organ failure and death," Distinguished Professor von Itzstein said.

Trial Details and the Path Forward

The Phase II trial was conducted by Grand Pharmaceutical Group Limited (Grand Pharma) and included 180 patients diagnosed with sepsis. Despite its global impact, there is currently no specific anti-sepsis therapy available, making the condition a major unmet medical need.

Professor von Itzstein said Grand Pharma now plans to move the treatment into a Phase III trial to further evaluate its effectiveness.

"It's hoped we could see the treatment reach the market in a handful years, potentially saving millions of lives," he said.

Broader Impact of the Research

Professor Paul Clarke, Executive Director of the Institute for Biomedicine and Glycomics, welcomed the results of the trial.

"I am thrilled to see the results of the trial which ultimately aims to save lives," Professor Clarke said.