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Addition of acetaminophen to ibuprofen fails to improve control of endodontic pain: Study

Dr. Shravani DaliWritten by Dr. Shravani Dali Published On 2024-05-24T20:00:43+05:30  |  Updated On 24 May 2024 8:01 PM IST
Addition of acetaminophen to ibuprofen fails to improve control of endodontic pain: Study
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The addition of acetaminophen to ibuprofen fails to improve control of endodontic pain suggests a study published in the Journal of endodontics

Most pain studies have been based on a postsurgical, third molar model using ibuprofen (IBU)/acetaminophen (APAP). Studies have found quicker onset of pain relief with a newer formulation of IBU - ibuprofen sodium dihydrate (ISD). The purpose of this study was to compare pain reduction of ISD/APAP to ISD in an acute endodontic pain model of untreated patients experiencing moderate to severe pain with symptomatic apical periodontitis. In this double-blind randomized study, 64 adult emergency patients in acute moderate to severe pain, a pulpal diagnosis of symptomatic irreversible pulpitis or necrosis, and symptomatic apical periodontitis participated. Each patient randomly received either one dose of 768 mg ISD/1000 mg APAP or one dose of 768 mg ISD. Pain intensity scores were recorded every 15 minutes over 240 minutes using the Heft-Parker VAS along with time to first sign of pain relief, time to meaningful pain relief, and time to 50% pain relief also recorded. The data were analyzed statistically. Results: Both ISD and ISD/APAP groups showed a progressive decrease in pain from baseline to 120 minutes after medication administration. Afterward, a relative plateau was seen in the patients’ pain. There was no difference in the VAS scores between the ISD and ISD/APAP at any given time point, time to first sign of pain relief, time to meaningful pain relief, and time to 50% pain relief. The addition of APAP to ISD for pain control in an untreated endodontic pain model did not differ significantly from ISD alone.

Reference:

Palya M, Chevere JM, Drum M, Fowler S, Nusstein J, Reader A, Ni A. Pain Reduction of Ibuprofen Sodium Dihydrate Alone and in Combination with Acetaminophen in an Untreated Endodontic Pain Model: A Randomized, Double-blind Investigation. J Endod. 2024 Apr 23:S0099-2399(24)00231-0. doi: 10.1016/j.joen.2024.04.005. Epub ahead of print. PMID: 38657900.

Keywords:

Addition, acetaminophen, ibuprofen, fails, improve, control, endodontic pain, study, Acetaminophen, endodontic pain, ibuprofen sodium dihydrate, journal of endodontics, Palya M, Chevere JM, Drum M, Fowler S, Nusstein J, Reader A, Ni A





Additionacetaminophenibuprofenfailsimprovecontrolendodontic painstudy
Source : journal of endodontics
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

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