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Melatonin significantly increases efficacy of full-mouth scaling and root planing in patients with diabetes and periodontitis

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-02-13T20:00:37+05:30  |  Updated On 13 Feb 2024 8:00 PM IST
Melatonin significantly increases efficacy of full-mouth scaling and root planing in patients with diabetes and periodontitis
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In a groundbreaking clinical study addressing the intricate relationship between diabetes mellitus (DM) and periodontitis, researchers have unveiled a promising breakthrough that could transform the landscape of nonsurgical periodontal therapy. This innovative investigation delves into the clinical efficacy of melatonin supplementation as a host modulation agent in diabetic patients with periodontitis, providing a unique perspective on its potential as a therapeutic adjunct.

The study results were published in the Journal of Periodontology.

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Diabetes mellitus (DM) has long been associated with an exaggerated inflammatory response, exacerbating periodontal tissue destruction. Literature shows that the application of host modulation agents to enhance nonsurgical periodontal therapy in individuals with diabetes is an actively researched area. Hence, researchers conducted a study to investigate the clinical efficacy of melatonin supplementation and shed light on its underlying biological mechanisms by examining fundamental markers.

The randomized controlled, single-blind study involved 55 diabetic patients with periodontitis, with 27 undergoing full-mouth scaling and root planing (fmSRP) alone and 28 receiving melatonin supplementation (6 mg daily for 30 days) in addition to fmSRP (full-mouth scaling and root planing plus melatonin, fmSRP-mel). The impact of melatonin was assessed clinically and biochemically through the analysis of gingival crevicular fluid RANKL, OPG, MMP-8, and serum IL-1β levels at the 3rd and 6th months.

Findings:

  • Results from the study indicated that melatonin, administered in tablet form at 6 mg daily for 30 days, did not induce any local or systemic side effects.
  • FmSRP alone demonstrated a significant reduction in serum IL-1β levels, pocket depths, gingival inflammation, and gingival crevicular fluid RANKL and MMP-8 levels (p < 0.05).
  • Interestingly, melatonin supplementation led to a more pronounced decrease in bleeding and pocket depth scores during probing, particularly at the 3-month mark (p < 0.05).
  • Furthermore, RANKL and MMP-8 levels exhibited a significant reduction at 3 months, while IL-1β levels decreased at 6 months compared to the control group (p < 0.05).
  • Notably, OPG levels were not significantly affected by the treatments (p > 0.05).
Also Read: Socket-shield therapy promising for preserving inter-implant papilla between adjacent central-lateral incisor implants

In conclusion, melatonin, as a host modulation agent, demonstrated a significant enhancement in the clinical efficacy of fmSRP. The observed reduction in periodontal inflammation and pocket depths is attributed to melatonin's marked suppression of RANKL-associated osteoclastogenesis and extracellular matrix damage. This breakthrough offers a promising avenue for improved periodontal treatment outcomes in diabetic individuals, showcasing melatonin's potential as a therapeutic adjunct in managing periodontitis in this specific patient population.

Further reading: Melatonin supports nonsurgical periodontal treatment in patients with Type 2 diabetes mellitus and periodontitis: A randomized clinical trial. Doi: https://doi.org/10.1002/JPER.23-0335

Journal of PeriodontologyPeriodonticsnonsurgical periodontal treatmentMelatonin
Source : Journal of Periodontology
Dr.Niharika Harsha B
Dr.Niharika Harsha B

    BDS, MDS

    Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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