Pre-operative clindamycin may not reduce implant failure or complications after dental surgery

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-12-29T20:00:36+05:30 | Updated On 30 Dec 2022 4:50 PM IST

Oral implants are considered a predictable and safe treatment modality for the rehabilitation of missing teeth. However, there are reports on oral implant failure and one of main reasons for this is postoperative infections. The bacterial contamination of the implant bed during surgery are a significant cause of early implant failure, as well as being associated with late implant failure.

Pre-operative clindamycin administration during dental implant surgery in healthy adults may not reduce implant failure or post-surgical complications suggests a Prospective randomised placebo-controlled clinical trial.

The findings of the clinical trial have been published in the Evidence-Based Dentistry.

Clindamycin is a lincosamide type of antibiotic that's used to treat a variety of bacterial infections, including dental infection. It is usually given through oral route.

Sixty-two healthy adults who underwent single dental implant placement without previous infection of the surgical bed or the need for bone grafting were included in this clinical trial. They were randomly divided into two groups (test and control). The test group was given a single dose of oral clindamycin (600 mg) one hour before surgery and the control group with a placebo. The surgical procedures were carried out by one oral surgeon and all the patients were observed post-operatively on days 1, 7, 14, 28, and 56 by a single observer for clinical, radiological, and surgical variables, adverse events, and complications. Statistical analysis was performed with STATA 15 software and the number required to treat or harm (NNT/NNH) was also evaluated.

Results

In the test group, the authors observed two implant failures and one patient experienced gastrointestinal disturbances and diarrhoea.

They also observed post-operative infections in three patients (two in the control group and one in the test group which eventually failed).

The authors concluded that pre-operative clindamycin administration during dental implant surgery in healthy adults may not reduce implant failure or post-surgical complications.

Reference:

Subramani, K. Does pre-operative clindamycin administration during dental implant surgery reduce implant failure or post-surgical complications?. Evid Based Dent 23, 140–141 (2022). https://doi.org/10.1038/s41432-022-0838-6

clindamycinsurgical complicationspreoperative careimplant

Source : Evidence Based Dentistry

Dr. Shravani Dali

Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751