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  • Rapamycin enhances...

Rapamycin enhances whole gland homeostasis and alleviates irradiation-induced parotid injury: Study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-12-23T21:00:54+05:30  |  Updated On 24 Dec 2024 12:22 PM IST
Rapamycin enhances whole gland homeostasis and alleviates irradiation-induced parotid injury: Study
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Rapamycin enhances whole gland homeostasis and alleviates irradiation-induced parotid injury suggests a study published in the Oral Diseases.

Salivary gland injury is one of the most common complications of radiotherapy in head-and-neck cancers.

This study investigated the mechanism by which rapamycin prevents irradiation (IR)-induced injury in the parotid glands. Miniature pigs either received (a) no treatment (NT), (b) IR in the right parotid gland for 5 consecutive days (IR), or intraperitoneal administration of rapamycin (Rap) 1 h prior to IR (IR + Rap). Tissues were collected at three distinct time points (24 h, 4 weeks, and 16 weeks) after IR. Histological analyses, western blot, and real-time reverse transcriptase-polymerase chain reaction were performed to explore the mechanisms of IR-induced injury in the parotid gland.

Results: Rapamycin treatment maintained parotid salivary flow 16 weeks post-IR, preserved the number of acinar cells, and reduced parotid tissue fibrosis, as well as reduced apoptosis levels, decreased cleaved caspase-3 expression, and increased the Bcl-2/Bax ratio in the parotid glands. Autophagy marker LC3B was upregulated by rapamycin after IR, while P62 expression was downregulated. Rapamycin reduced the expression of pro-inflammatory factors and the mesenchymal tissue fibrosis following IR. Rapamycin maintains gland homeostasis after IR by decreasing apoptosis, reducing the expression of pro-inflammatory factors, and enhancing autophagy.

Reference:

Zhu, Z., Song, J., Zhang, C., Zhang, J., & Shan, Z. (2024). Rapamycin alleviates irradiation-induced parotid injury by enhancing the whole gland homeostasis. Oral Diseases, 30, 5050–5061. https://doi.org/10.1111/odi.14948

Rapamycinenhanceswholeglandhomeostasisalleviatesirradiation-inducedparotidinjurystudy
Source : Oral Diseases
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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