Specialized proresolving mediators crucial for treating pulpal-periapical diseases: Study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-10-26T09:00:05+05:30 | Updated On 26 Oct 2021 9:00 AM IST

Specialized proresolving mediators (SPMs) are crucial in the inception and treatment of pulpal-periapical diseases, suggests a study published in the Journal of Endodontics.

Proresolving lipid mediators are specialized molecules (SPMs) involved in the active resolution of the inflammatory process by regulating tissue homeostasis.

A group of researchers conducted a study to investigate the scientific literature to assess the potential of SPMs as an adjunct in the treatment of endodontic infection.

Three electronic databases (PubMed, Web of Science, and Scopus) were searched from their inception until February 2020 (PROSPERO CRD42020164743). Supplemental research was performed by screening the references of the relevant studies eligible for inclusion. A quality assessment of animal studies was performed using the Animal Research: Reporting of In Vivo Experiments guidelines, whereas the Systematic Review Centre for Laboratory animal Experimentation Risk of Bias tool was used to assess the risk of bias.

The results of the study are as follows:

· A total of 3295 records were screened, and 8 articles meeting the criteria were included for this qualitative review.

· The eligible studies showed a high to moderate overall quality and a low to moderate risk of bias.

· Specialized pro-resolving mediators (SPMs) positively affected the development of pulpitis and apical periodontitis in experimental animal models.

· The early treatment of pulpitis with the topical application of Specialized pro-resolving mediators (SPMs) was beneficial to control inflammation within 24 hours from contamination.

· In addition, Specialized pro-resolving mediators (SPMs) delivered within the root canals after disinfection were found effective in promoting periapical healing.

Thus, the researchers concluded that Specialized pro-resolving mediators (SPMs) may play a role in the inception and treatment of pulpal-periapical diseases, and they should be considered for future research for developing new therapeutics as an adjunct to endodontic treatment.

Reference:

Proresolving Mediators in Endodontics: A Systematic Review by Cotti E et. al published in the Journal of Endodontics.

https://doi.org/10.1016/j.joen.2021.01.008

pulp-periapical cariesendodonticsspmapical periodontitisspecialized proresolving mediatorsvital pulp therapyjournal of endodontics

Source : Journal of Endodontics

Dr. Shravani Dali

Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751