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Tobacco enhances pathogenicity of Filifactor alocis leading to Periodontitis

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-11-09T20:00:35+05:30  |  Updated On 9 Nov 2022 8:00 PM IST
Tobacco enhances pathogenicity of Filifactor alocis leading to Periodontitis
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Tobacco enhances pathogenicity of Filifactor alocis leading to Periodontitis suggests a recent study published in the Journal of Clinical Periodontology

Tobacco smoke is a sooty aerosol produced by the incomplete combustion of tobacco during the smoking of cigarettes and other tobacco products. All forms of tobacco are harmful, and there is no safe level of exposure to tobacco. Filifactor alocis has recently emerged as a periodontal pathobiont that appears to thrive in the oral cavity of smokers. We hypothesized that identification of smoke-responsive Filifactor alocis genes would provide insight into adaptive strategies and that cigarette smoke would enhance F. alocis pathogenesis in vivo.

Filifactor alocis was grown in vitro and cigarette smoke extract-responsive genes determined by RNAseq. Mice were exposed, or not, to mainstream 1R6F research cigarette smoke and infected with F. alocis, or not, in an acute ligature model of periodontitis. Key clinical, infectious, and immune data were collected.

Results

  • In culture, F. alocis growth was unaffected by smoke conditioning and only a small number of genes were specifically regulated by smoke exposure.
  • Reduced murine mass, differences in F. alocis-cognizant antibody production, and altered immune profiles as well as altered alveolar bone loss were all attributable to smoke exposure and/or F. alocis infection in vivo.

Thus, F. alocis is well-adapted to tobacco-rich conditions and its pathogenesis is enhanced by tobacco smoke exposure. A smoke-exposed ligature model of periodontitis shows promise as a tool with which to further unravel mechanisms underlying tobacco-enhanced, bacteria-induced disease.

Reference:

Iskander, M. M. Z., Lamont, G. J., Tan, J., Pisano, M., Uriarte, S. M., & Scott, D. A. (2022). Tobacco smoke exacerbates Filifactor alocis pathogenicity. Journal of Clinical Periodontology, 1– 10. https://doi.org/10.1111/jcpe.13729

Keywords:

Tobacco, enhances, pathogenicity, Filifactor, alocis, Periodontitis, Journal of Clinical Periodontology, Mina M. Z. Iskander, Gwyneth J. Lamont, Jinlian Tan, Michele Pisano,Silvia M. Uriarte, David A. Scott


TobaccopathogenicityFilifactor alocisPeriodontitisJournal of Clinical Periodontology
Source : Journal of Clinical Periodontology
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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