Blood Metabolites May Have Causal Links with Alopecia Areata: Study
Researchers have found in a new study a potential causal associations between alopecia areata and blood levels of glutamine, citric acid, glucose, as well as various lipids and lipoproteins. Initial analyses showed no evidence of reverse causality, though further studies are needed to validate these findings.
Alopecia areata (AA) is an autoimmune hair loss disorder that affects approximately 2% of the global population, imposing a substantial psychological burden and impairing the quality of life. Although observational studies have correlated blood metabolites with AA, these associations are susceptible to confounding and reverse causality, leaving the causal direction unclear. This study employed a 2-sample Mendelian randomization (MR) approach to infer the causal relationship between blood metabolites and AA.
This study used publicly available genome-wide association study summary statistics for blood metabolites (Kettunen et al, N = 24,925) and AA (FinnGen, 682 cases/361,140 controls), both based on European ancestry populations. Single-nucleotide polymorphisms significantly associated with metabolites were selected as instrumental variables, while those in linkage disequilibrium or with an F-statistic < 10 were excluded to ensure the robustness of the instruments. The primary analysis utilized the inverse variance weighted method, supplemented by MR-Egger, weighted median, and MR-PRESSO analyses to assess horizontal pleiotropy and heterogeneity. A leave-one-out sensitivity analysis was performed to evaluate the influence of individual single-nucleotide polymorphisms.
Reference:
Yang, Xiao-Shuang, et al. "Causal Effects of Glutamine and Lipid-related Metabolites On Alopecia Areata: a 2-sample Mendelian Randomization Study." Medicine, vol. 104, no. 50, 2025, pp. E46312.
